Table of Contents

1 

Front Matter

Foreword by Bob Geng, MD

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Preface by Lauren Loop Galli

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Acknowledgment of Support

2

Acute Urticaria

Authors: Cathleen Collins, MD and Kathleen Luskin, MD

Editor: Kathleen Luskin, MD

Definiton & Diagnosis

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Etiology

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Differential Diagnosis & Mechanism

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Evaluation​

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Treatment, Prognosis & Associated and Emerging Conditions

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References​

3

Chronic Spontaneous Urticaria (CSU)

Authors: Reid Oldenburg, MD, PhD, FAAD and Kathleen Luskin, MD

Editor: Kathleen Luskin, MD

Overview

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Etiology

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Evaluation

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Work-Up

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Management

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Treatment

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References

4

Chronic Inducible Urticaria (CIndU)/Physical Urticaria

Authors: Kathryn Smiley, PA-C and Kathleen Luskin, MD

Editor: Kathleen Luskin, MD

Overview & Epidemiology

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Pathophysiology

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Pathophysiology - Table

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Diagnosis

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Management

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References

5

The Spectrum of Mast Cell Activation Syndromes

Authors: Kelli W. Williams, MD, MPH and Kathleen Luskin, MD

Editor: Kathleen Luskin, MD 

Overview

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Introduction

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Diagnostic criteria and classification of mast cell activation syndromes

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Primary (clonal) mast cell activation syndromes

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Secondary (non-clonal) mast cell activation syndrome

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Idiopathic mast cell activation syndrome, idiopathic anaphylaxis 

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Other mast cell disorders 

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Summary

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Table 1. Typical clinical symptoms of mast cell activation syndromes 

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Table 2. 2016 World Health Organization diagnostic criteria for systemic mastocytosis

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Figure 1. Classification of mast cell activation syndromes and diagnostic features 

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References

6

Clinical Approach to MCAS Diagnosis and Cutaneous Mastocytosis

Authors: Susan Laubach, MD and Kathleen Luskin, MD

Editor: Kathleen Luskin, MD

Introduction

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Signs and symptoms of MC mediator release 

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Mast Cell Activation Syndrome

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Diagnosis and Treatment of MCAS (Part 1 of 3)

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Diagnosis and Treatment of MCAS  (Part 2 of 3)

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Diagnosis and Treatment of MCAS (Part 3 of 3)

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Cutaneous Matocytosis (CM)

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Diagnosis & Treatment of CM

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Figure 1. Mast cell mediators and symptoms

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Table 1. Variants of MCAS

Figure 3. MCAS clinical criterion vs nonspecific symptoms and conditions that do not qualify as features of MCAS

Table 2. Differential diagnosis of MCAS 

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Table 3. Biochemical tests for MCAS

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Table 4. Pharmacotherapy for mast-cell derived symptoms

Table 5. Features of Cutaneous Mastocytosis (CM) in Children vs Adults

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References