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The Spectrum of Mast Cell Activation Syndromes
Table 2. 2016 World Health Organization diagnostic criteria for systemic mastocytosis
MAJOR CRITERION | MAJOR CRITERION |
• Presence of characteristic multifocal dense mast cell infiltrates (of ≥ 15 mast cells in aggregates) in bone marrow biopsies and/or an extracutaneous organ (e.g. spleen) | • > 25% of all mast cells are atypical or spindle-shaped • Detection of a KIT activating point mutation at codon 816 or in other critical regions of KIT • Expression of CD2 and/or CD25 and/or CD30 on the mast cells in bone marrow • Baseline serum tryptase is > 20 ng/mL |
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